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rabbit anti dpp6 (Sino Biological)

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Sino Biological rabbit anti dpp6
Rabbit Anti Dpp6, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+anti+dpp6/DPP6+Antibody%2C+Rabbit+PAb%2C+Antigen+Affinity+Purified/pmc12232208-1087-0-3
Average 93 stars, based on 1 article reviews

rabbit anti dpp6 - by Bioz Stars, 2026-09

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Article Title: Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice
Article Snippet: Rabbit anti-DPP6 , Sino Biological , 100592-T36;.

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Strategy for the generation of conditional DPP6 knockout mice . (A) LoxP sites were introduced flanking exon 2 of the DPP6 gene. Floxed mice were bred to a Cre deleter strain expressing Cre recombinase in the germline to generate null alleles. (B) Genotyping for DPP6 alleles. Amplification products of wildtype, heterozygote and homozygote nulls following PCR with primers DPPXF1 and DPPXB1. (C) RT-PCR of rat brain mRNA demonstrates lack of DPP6 transcripts in DPP6 −/− mice. PCR of GAPDH mRNA was used as control.

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Strategy for the generation of conditional DPP6 knockout mice . (A) LoxP sites were introduced flanking exon 2 of the DPP6 gene. Floxed mice were bred to a Cre deleter strain expressing Cre recombinase in the germline to generate null alleles. (B) Genotyping for DPP6 alleles. Amplification products of wildtype, heterozygote and homozygote nulls following PCR with primers DPPXF1 and DPPXB1. (C) RT-PCR of rat brain mRNA demonstrates lack of DPP6 transcripts in DPP6 −/− mice. PCR of GAPDH mRNA was used as control.

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Knock-Out, Expressing, Amplification, Reverse Transcription Polymerase Chain Reaction, Control

Specificity of antibodies against DPP6 proteins . (A) DPP6 antibodies detected a band of approximately 115 kD in immunoblots of extracts from CHO cells transfected with DPP6-S (lane 1) or DPP6-L (lane 3). The antibodies were specific for detection of DPP6 proteins, since no bands were detected in extracts from non-transfected cells (lane 2) or cells transfected with DPP10 (lane 4). All cells were also transfected with GFP to control for transfection efficiency. (B) DPP6 antibodies detected a band of similar size in immunoblots of brain membranes obtained from wild type mice (lane 1) but not from DPP6 knockout mice (lane 2). (C) Immunofluorescent detection of DPP6 protein in DPP6-transfected CHO cells (left panel). No labeling is observed in untransfected CHO cells (right panel). Note that, as previously reported, transfection with DPPs produces flattening of CHO cells (Nadal et al., ; Zagha et al., ). (D) DPP6 antibodies labeled several brain structures in wild type mice. Immunoperoxidase staining was reduced to background levels in DPP6 knockout mice. Scale bar: 10 μm (C) ; 2 mm (D) .

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Specificity of antibodies against DPP6 proteins . (A) DPP6 antibodies detected a band of approximately 115 kD in immunoblots of extracts from CHO cells transfected with DPP6-S (lane 1) or DPP6-L (lane 3). The antibodies were specific for detection of DPP6 proteins, since no bands were detected in extracts from non-transfected cells (lane 2) or cells transfected with DPP10 (lane 4). All cells were also transfected with GFP to control for transfection efficiency. (B) DPP6 antibodies detected a band of similar size in immunoblots of brain membranes obtained from wild type mice (lane 1) but not from DPP6 knockout mice (lane 2). (C) Immunofluorescent detection of DPP6 protein in DPP6-transfected CHO cells (left panel). No labeling is observed in untransfected CHO cells (right panel). Note that, as previously reported, transfection with DPPs produces flattening of CHO cells (Nadal et al., ; Zagha et al., ). (D) DPP6 antibodies labeled several brain structures in wild type mice. Immunoperoxidase staining was reduced to background levels in DPP6 knockout mice. Scale bar: 10 μm (C) ; 2 mm (D) .

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Western Blot, Transfection, Control, Knock-Out, Labeling, Immunoperoxidase Staining

DPP6 and Kv4.2 are expressed in similar structures in mouse brain . (A,B) Both Kv4.2 and DPP6 proteins are widely distributed throughout the mouse brain. The three structures most prominently labeled with Kv4.2 antibodies (A) the striatum (STR), hippocampus (HPF) and cerebellar (CB) cortex, are prominently labeled by antibodies to DPP6 (B) . (C,D) Magnification of the Kv4.2 (C) and DPP6 (D) immunostaining of the striatum. As previously reported for antibodies to Kv4.2 and KChIPs (Rhodes et al., ) the labeling is concentrated in the neuropil. Neuronal somata are weakly labeled and are not apparent. All images are immunoperoxidase staining. Scale bar: 2 mm (A,B) ; 100 μm (C,D) .

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: DPP6 and Kv4.2 are expressed in similar structures in mouse brain . (A,B) Both Kv4.2 and DPP6 proteins are widely distributed throughout the mouse brain. The three structures most prominently labeled with Kv4.2 antibodies (A) the striatum (STR), hippocampus (HPF) and cerebellar (CB) cortex, are prominently labeled by antibodies to DPP6 (B) . (C,D) Magnification of the Kv4.2 (C) and DPP6 (D) immunostaining of the striatum. As previously reported for antibodies to Kv4.2 and KChIPs (Rhodes et al., ) the labeling is concentrated in the neuropil. Neuronal somata are weakly labeled and are not apparent. All images are immunoperoxidase staining. Scale bar: 2 mm (A,B) ; 100 μm (C,D) .

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Labeling, Immunostaining, Immunoperoxidase Staining

Immunolocalization of Kv4.2 and DPP6 proteins in pontine nuclei . Kv4.2 antibodies (A) and DPP6 antibodies (B) both prominently labeled the neuropil of the pontine nuclei. Immunoperoxidase staining. Scale bar: 250 μm.

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Immunolocalization of Kv4.2 and DPP6 proteins in pontine nuclei . Kv4.2 antibodies (A) and DPP6 antibodies (B) both prominently labeled the neuropil of the pontine nuclei. Immunoperoxidase staining. Scale bar: 250 μm.

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Labeling, Immunoperoxidase Staining

Immunolocalization of Kv4 and DPP6 in the mouse hippocampus . (B–D) Immunofluorescent staining for Kv4.2, Kv4.3 and DPP6 is concentrated in dendritic fields, including the apical and basal dendrites of CA pyramidal cells and the apical dendritic fields of the granule cells in the dentate gyrus (DG). The somata and dendrites of GABAergic interneurons are stained with Kv4.3, but not with Kv4.2 or DPP6 antibodies. The mossy fibers (MF) are labeled with antibodies to DPP6, but not with antibodies to Kv4.2 or Kv4.3. (A) As reference, the hippocampus of a Thy1-H YFP mouse (Feng et al., ) expressing YFP in a subset of pyramidal cells in the CA1–CA3 fields and granule cells of the DG is shown. Note the labeled cell bodies and dendrites of pyramidal and granule cells. The axons of the granule cells (MF) are also YFP labeled. Scale bar: 200 μm. SO, stratum oriens; SR, stratum radiatum; SM, stratum moleculare; SL, stratum lucidum; SLM, stratum lacunosum moleculare.

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Immunolocalization of Kv4 and DPP6 in the mouse hippocampus . (B–D) Immunofluorescent staining for Kv4.2, Kv4.3 and DPP6 is concentrated in dendritic fields, including the apical and basal dendrites of CA pyramidal cells and the apical dendritic fields of the granule cells in the dentate gyrus (DG). The somata and dendrites of GABAergic interneurons are stained with Kv4.3, but not with Kv4.2 or DPP6 antibodies. The mossy fibers (MF) are labeled with antibodies to DPP6, but not with antibodies to Kv4.2 or Kv4.3. (A) As reference, the hippocampus of a Thy1-H YFP mouse (Feng et al., ) expressing YFP in a subset of pyramidal cells in the CA1–CA3 fields and granule cells of the DG is shown. Note the labeled cell bodies and dendrites of pyramidal and granule cells. The axons of the granule cells (MF) are also YFP labeled. Scale bar: 200 μm. SO, stratum oriens; SR, stratum radiatum; SM, stratum moleculare; SL, stratum lucidum; SLM, stratum lacunosum moleculare.

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Staining, Labeling, Expressing

Enrichment of Kv4.2 and DPP6 in CA1 pyramidal cell dendrites . Confocal image of the CA1 field of the hippocampus in mouse double immunostained for Kv4.2 ( A , pseudocolored red) and DPP6 ( B , pseudocolored green) and the overlay of the two channels (C) . Strong staining of the stratum radiatum (SR) was evident with both antibodies, however DPP6 antibodies produced stronger staining in the SLM than Kv4.2. (D–F) Higher magnification confocal image of CA1. Strong staining with both antibodies is observed in pyramidal cells' apical and basal dendrites, while pyramidal cell somata are only weakly stained. Scale bar: 50 μm (A–C) ; 20 μm (D–F) .

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Enrichment of Kv4.2 and DPP6 in CA1 pyramidal cell dendrites . Confocal image of the CA1 field of the hippocampus in mouse double immunostained for Kv4.2 ( A , pseudocolored red) and DPP6 ( B , pseudocolored green) and the overlay of the two channels (C) . Strong staining of the stratum radiatum (SR) was evident with both antibodies, however DPP6 antibodies produced stronger staining in the SLM than Kv4.2. (D–F) Higher magnification confocal image of CA1. Strong staining with both antibodies is observed in pyramidal cells' apical and basal dendrites, while pyramidal cell somata are only weakly stained. Scale bar: 50 μm (A–C) ; 20 μm (D–F) .

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Staining, Produced

Immunolocalization of Kv4.2 and DPP6 proteins in the cerebellar cortex . Confocal fluorescent images of the cerebellar cortex single labeled with antibodies to Kv4.2 ( A , pseudocolored red) or DPP6 ( B , pseudocolored green). Immunostaining for both Kv4.2 and DPP6 is prominent in the granule cell layer (G), while the molecular layer (M) is weakly stained in both instances. Also, neither antibody labeled Purkinje cells (P). The insets show high magnifications of the granule cell layer demonstrating high density labeling of the cerebellar glomeruli (arrowheads). Granule cell somata are more weakly stained, and the label is restricted to the periphery of the cell. Scale bars: 100 μm for main panels in (A) and (B) ; 10 μm for the insets in (A) and (B) . (C,D) Immunoperoxidase staining showing anterior-posterior gradient of expression of Kv4.2 and DPP6 proteins in the granule cell layer in lateral cerebellar lobules. Shown are sagittal sections of the mouse cerebellum immunostained with antibodies to Kv4.2 (C) or DPP6 (D) . Immunolabeling for both, Kv4.2 and DPP6, is more prominent in anterior than posterior lobules. Scale bar: 1 mm for (C) and (D) .

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Immunolocalization of Kv4.2 and DPP6 proteins in the cerebellar cortex . Confocal fluorescent images of the cerebellar cortex single labeled with antibodies to Kv4.2 ( A , pseudocolored red) or DPP6 ( B , pseudocolored green). Immunostaining for both Kv4.2 and DPP6 is prominent in the granule cell layer (G), while the molecular layer (M) is weakly stained in both instances. Also, neither antibody labeled Purkinje cells (P). The insets show high magnifications of the granule cell layer demonstrating high density labeling of the cerebellar glomeruli (arrowheads). Granule cell somata are more weakly stained, and the label is restricted to the periphery of the cell. Scale bars: 100 μm for main panels in (A) and (B) ; 10 μm for the insets in (A) and (B) . (C,D) Immunoperoxidase staining showing anterior-posterior gradient of expression of Kv4.2 and DPP6 proteins in the granule cell layer in lateral cerebellar lobules. Shown are sagittal sections of the mouse cerebellum immunostained with antibodies to Kv4.2 (C) or DPP6 (D) . Immunolabeling for both, Kv4.2 and DPP6, is more prominent in anterior than posterior lobules. Scale bar: 1 mm for (C) and (D) .

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Labeling, Immunostaining, Staining, Immunoperoxidase Staining, Expressing, Immunolabeling

Double-labeling of Cerebellum with Kv4.2 and DPP6 antibodies . Low magnification of cerebellum showing confocal immumofluorescence staining of Kv4.2 (A) , DPP6 (B) , and the overlay of the two images (C) . (D–F) High magnification confocal images of granule cell layer double-labeled with Kv4.2 (D) and DPP6 (E) antibodies showing colocalization in cerebellar granule cells. Scale bar: 100 μm in upper panels; 20 μm in lower panels.

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: Double-labeling of Cerebellum with Kv4.2 and DPP6 antibodies . Low magnification of cerebellum showing confocal immumofluorescence staining of Kv4.2 (A) , DPP6 (B) , and the overlay of the two images (C) . (D–F) High magnification confocal images of granule cell layer double-labeled with Kv4.2 (D) and DPP6 (E) antibodies showing colocalization in cerebellar granule cells. Scale bar: 100 μm in upper panels; 20 μm in lower panels.

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Labeling, Staining

DPP6, but not Kv4.2, is expressed in the hippocampal mossy fibers . Confocal images of the hippocampus of a Thy1-H mouse expressing YFP (green) in the mossy fibers (MF) double labeled for Kv4.2 (red) and DPP6 (light blue). The three images are shown superimposed in the lower right panel (merge). Note the strong immunolabeling of the mossy fibers in the stratum lucidum with DPP6 antibodies and lack of staining with antibodies to Kv4.2. Scale bar: 50 μm.

Journal: Frontiers in Molecular Neuroscience

Article Title: DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein

doi: 10.3389/neuro.02.008.2008

Figure Lengend Snippet: DPP6, but not Kv4.2, is expressed in the hippocampal mossy fibers . Confocal images of the hippocampus of a Thy1-H mouse expressing YFP (green) in the mossy fibers (MF) double labeled for Kv4.2 (red) and DPP6 (light blue). The three images are shown superimposed in the lower right panel (merge). Note the strong immunolabeling of the mossy fibers in the stratum lucidum with DPP6 antibodies and lack of staining with antibodies to Kv4.2. Scale bar: 50 μm.

Article Snippet: Rabbit anti-DPP6 antibodies and mouse monoclonal anti-Kv4.2; K57/1 and anti-Kv4.3 K75/41 Neuromab; www.neuromab.org were used for immunolocalization experiments in brain.

Techniques: Expressing, Labeling, Immunolabeling, Staining

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rabbit anti dpp6 (Sino Biological)

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